Anne Baudry , Facet for Adaptive Responses to Antidepressants MiR - 16 Targets the Serotonin Transporter : A New
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. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of October 1, 2010 ): The following resources related to this article are available online at www.sciencemag.org http://www.sciencemag.org/cgi/content/full/329/5998/1537 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/329/5998/1537/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/329/5998/1537#related-content http://www.sciencemag.org/cgi/content/full/329/5998/1537#otherarticles , 5 of which can be accessed for free: cites 20 articles This article http://www.sciencemag.org/cgi/collection/neuroscience Neuroscience : subject collections This article appears in the following
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Anne Baudry Responses to Antidepressants MiR - 16 Targets the Serotonin Transporter : A New Facet for Adaptive
, 1537 (2010); 329 Science et al. Anne Baudry Responses to Antidepressants MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by P...
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The serotonin transporter (SERT) ensures the recapture of serotonin and is the pharmacological target of selective serotonin reuptake inhibitor (SSRI) antidepressants. We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression. In mice, chronic trea...
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The serotonin transporter (SERT) is a key regulatory molecule in serotonergic transmission implicated in numerous biological processes relevant to human disorders. Recently, it was shown that SERT expression is controlled by miR-16 in mouse brain. Here, we show that SERT expression is regulated additionally by miR-15a as well as miR-16 in human and rat tissues. This post-transcriptional regulat...
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